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The body's immune system produces antibodies to attack and help destroy invading viruses and bacteria.

These specific EBV antibodies can be detected in the blood of people who have been infected with mono.

Mono is confirmed by blood tests that may also include tests to exclude other possible causes of the symptoms, such as tests to rule out strep throat.

Early in the course of the mono, blood tests may show an increase in one type of white blood cell (lymphocyte).

Having a sore throat can be a symptom of many conditions, and many people wonder if their own sore throat might be a sign of something more serious than the common cold.

During an infection, the contagious period in which a person is likely able to transmit the virus to others lasts for at least a few weeks and possibly longer, even after symptoms have disappeared (see below).

When infection occurs in childhood, the virus most often produces no symptoms.

It is estimated that only about 10% of children who become infected with EBV develop the illness.

The tonsils have a whitish coating in at least one-third of the cases.

The spleen (sometimes referred to as the body's biggest lymph node) is an organ found in the left upper abdomen underneath the rib cage, which becomes enlarged or swollen in about half of patients with mono.