Non sedating anti

12 Oct

Scopolamine and atropine are nonspecific muscarinic receptor antagonists (Barton et al, 1994; Soto et al, 2013).

Diphenidol (Vontrol), is also an anticholinergic, although little used in the US.

Histamine (H1-H3) is found diffusely in central vestibular structures and centrally acting antihistamines modulate symptoms of motion sickness (Takeda et al, 1989).

non sedating anti-82non sedating anti-67non sedating anti-26

Receptors found in the pons and medulla, presumably those involved with dizziness, are almost exclusively of the M2 subtype (Barton et al, 1994).However there are also nicotinic receptors, as well as M1 and M5 (Soto et al, 2013).In the CNS, the N or P/Q type are the ones that participate in neurotransmitter release.The term "vestibular suppressant" is a vague one generally used to indicate drugs that reduce nystagmus evoked by a vestibular imbalance or which reduce motion sickness.Table 1 lists commonly used vestibular suppressants, which consist of three major drug groups, the anticholinergics, the antihistamines, and the benzodiazepines.